acetyl coa การใช้

• Evidence suggests acetate kinase evolved in an ancient acetyl coA synthetase gene.
• This process continues until the entire chain is cleaved into acetyl CoA units.
• Concomitantly, one molecule of FADH 2, NADH and acetyl CoA are formed.
• The enzyme is a mitochondrial protein containing a biotin prosthetic group, requiring magnesium or manganese and acetyl CoA.
• They are commonly used in lipid synthesis, gluconeogenesis, conversion of pyruvate into Acetyl CoA via PDH complex.
• It can also be converted into Acetyl CoA and fed into the TCA cycle by condensing with oxaloacetate to form citrate.
• Acetyl CoA ( acetyl co-enzyme A ) will also build up, leading to the creation of ketone bodies.
• So I just added a ( small ) contribution to the Acetyl CoA question, and ran into an editing conflict.
• The cytosolic acetyl-CoA is carboxylated by acetyl CoA carboxylase into malonyl CoA, the first committed step in the synthesis of fatty acids.
• The cytosolic acetyl-CoA is carboxylated by acetyl CoA carboxylase into malonyl-CoA, the first committed step in the synthesis of fatty acids.
• In mammals Acetyl CoA cannot be converted back to carbohydrate but can be used in the synthesis of ketone bodies or fatty acids, hence ketogenic.
• The resulting enolate attacks CO 2 to form malonyl CoA . In a competing mechanism, proton abstraction is concerted with the attack of acetyl CoA.
• An NADPH-utilizing pathway forms NADP +, which stimulates Glucose-6-phosphate dehydrogenase to produce more NADPH . This step is also inhibited by acetyl CoA.
• In humans, arsenite inhibits pyruvate dehydrogenase ( PDH complex ) in the pyruvate acetyl CoA reaction, and binds to the  SH group of lipoamide, a participant coenzyme.
• Because dihydrolipoyl transacetylase is the second of the three enzyme components participating in the reaction mechanism for conversion of pyruvate into acetyl CoA, it is sometimes referred to as E2.
• The leucine synthesis pathway diverges from the valine pathway beginning with ?-ketoisovalerate . ?-Isopropylmalate synthase reacts with this substrate and Acetyl CoA to produce ?-isopropylmalate.
• In short, citrate is transported to the cytoplasm, converted to acetyl CoA, which is converted into malonyl CoA by the acetyl CoA carboxylase, which is allosterically modulated by citrate.
• In short, citrate is transported to the cytoplasm, converted to acetyl CoA, which is converted into malonyl CoA by the acetyl CoA carboxylase, which is allosterically modulated by citrate.
• The final cycle produces two separate acetyl CoAs, instead of one acyl CoA and one acetyl CoA . For every cycle, the Acyl CoA unit is shortened by two carbon atoms.
• The pyruvate dehydrogenase complex is responsible for the oxidative decarboxylation of pyruvate, with the final product being Acetyl CoA . Overall the complex catalyzes five reactions, with the overall reaction being: